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David Hope's avatar

I have lately become interested in a medical phenomenon of which I am sure you are aware: Spaceflight‑Associated Neuro‑Ocular Syndrome (SANS).

It appears to arise from a set of interrelated disturbances in cranial and orbital fluid mechanics, venous hemodynamics, and tissue biomechanics produced by prolonged exposure to microgravity. No single unifying mechanism has been proven; current clinical and translational evidence supports a multifactorial model in which cephalad fluid shifts trigger downstream alterations in cerebrospinal fluid (CSF) dynamics, translaminar pressure relationships, ocular interstitial fluid balance, and vascular structure/function. Individual anatomic and physiologic susceptibility factors modulate whether and how these primary perturbations produce optic nerve head edema, globe flattening, choroidal changes, and visual dysfunction.

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